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Search for "multistep synthesis optimization" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

Chinmay A. Shukla and
Amol A. Kulkarni

Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97

scale of operation. This classification will cover the broader range in the multistep synthesis literature. Keywords: automation; control strategy; flow chemistry; in-line monitoring; multistep synthesis optimization; Introduction Multistep flow synthesis In the recent time the concept of flow

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Graphical Abstract

Figure 1: A number of experiments for various optimization algorithms [46].

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Figure 2: Symbols used for block and P&ID diagrams.

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Scheme 1: Multistep synthesis of olanzapine (Hartwig et al. [10])

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Figure 3: (A) Block diagram representation of the process shown in Scheme 1, (B) piping and instrumentation diagram o...

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Scheme 2: Multistep flow synthesis for tamoxifen (Murray et al. [11]).

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Figure 4: (A) Block diagram representation of the process shown in Scheme 2, (B) piping and instrumentation diagram o...

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Figure 5: (A) Block diagram representation of the process shown in Scheme 3, (B) piping and instrumentation diagram o...

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Scheme 3: Multistep flow synthesis of rufinamide (Zhang et al. [14]).

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Figure 6: (A) Block diagram representation of the process shown in Scheme 4, (B) piping and instrumentation diagram o...

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Scheme 4: Multistep synthesis for (±)-Oxomaritidine (Baxendale et al. [9]).

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Figure 7: (A) Block diagram representation of the process shown in Scheme 5, (B) piping and instrumentation diagram o...

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Scheme 5: Multistep synthesis for ibuprofen (Snead and Jamison [60]).

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Scheme 6: Multistep synthesis for cinnarizine and buclizine derivatives (Borukhova et al. [23])

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Figure 8: (A) Block diagram representation of the process shown in Scheme 6, (B) piping and instrumentation diagram o...

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Scheme 7: Multistep synthesis for (S)-rolipram (Tsubogo et al. [4])

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Figure 9: (A) Block diagram representation of the process shown in Scheme 7 (colours for each reactor shows different...

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Figure 10: (A) Block diagram representation of the process shown in Scheme 8, (B) piping and instrumentation diagram o...

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Scheme 8: Multistep synthesis for amitriptyline (Kupracz and Kirschning [7]).

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Review

Published 19 May 2017

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